Item Type | Name |
Concept
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Protein Structure, Tertiary
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Concept
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Adaptor Protein Complex beta Subunits
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Concept
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Oncogene Protein v-akt
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Concept
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Cyclic AMP Response Element-Binding Protein
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Concept
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Protein Binding
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Protein Prenylation
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Concept
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Adaptor Protein Complex 1
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Concept
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Amyloid beta-Protein Precursor
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Concept
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Protein Folding
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Concept
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HMGN1 Protein
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Concept
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Protein Processing, Post-Translational
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Concept
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Fragile X Mental Retardation Protein
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Concept
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Interleukin-1 Receptor Accessory Protein
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Concept
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p38 Mitogen-Activated Protein Kinases
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Concept
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Receptors, G-Protein-Coupled
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Concept
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GTP-Binding Protein alpha Subunits, Gq-G11
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Concept
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Protein Biosynthesis
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Concept
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Synaptosomal-Associated Protein 25
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Concept
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Protein Phosphatase 2
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Concept
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Insulin-Like Growth Factor Binding Protein 5
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Concept
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Glial Fibrillary Acidic Protein
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Concept
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Protein Multimerization
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Concept
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Pregnancy-Associated Plasma Protein-A
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Concept
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Protein Stability
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Concept
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Protein Structure, Quaternary
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Concept
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Myelin Basic Protein
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Concept
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Amyloid Precursor Protein Secretases
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Concept
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Mitogen-Activated Protein Kinase Kinases
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Concept
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Protein Kinases
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Concept
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C-Reactive Protein
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Concept
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Receptor-Like Protein Tyrosine Phosphatases, Class 2
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Concept
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Protein Interaction Domains and Motifs
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Concept
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Protein Synthesis Inhibitors
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Concept
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Protein Isoforms
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Concept
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Protein Conformation
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Concept
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Protein Array Analysis
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Concept
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Protein Interaction Maps
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Concept
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Protein Aggregation, Pathological
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Concept
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Vesicular Glutamate Transport Protein 1
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Concept
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Fas-Associated Death Domain Protein
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Concept
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CREB-Binding Protein
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Academic Article
|
GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
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Academic Article
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GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.
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Academic Article
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Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.
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Academic Article
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Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
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Academic Article
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Cognitive reserve, presynaptic proteins and dementia in the elderly.
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Academic Article
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High CRP with "normal" cognition: a resilient phenotype in old age.
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Academic Article
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
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Academic Article
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Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
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Academic Article
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Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.
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Academic Article
|
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
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Academic Article
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Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.
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Academic Article
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Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans.
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Academic Article
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Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment.
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Academic Article
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Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.
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Academic Article
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Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease.
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Academic Article
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Contribution of changes in ubiquitin and myelin basic protein to age-related cognitive decline.
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Academic Article
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Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits.
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Academic Article
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Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathology.
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Academic Article
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Elevated A?42 in aged, non-demented individuals with cerebral atherosclerosis.
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Academic Article
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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.
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Academic Article
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Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scores.
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Academic Article
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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.
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Academic Article
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Fragile X gene expansions are not associated with dementia.
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Academic Article
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CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility.
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Academic Article
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Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease.
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Academic Article
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Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment.
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Academic Article
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Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.
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Academic Article
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The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.
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Academic Article
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Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.
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Academic Article
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Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment.
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Academic Article
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Brain amyloid-? oligomers in ageing and Alzheimer's disease.
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Academic Article
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ELISA measurement of specific non-antigen-bound antibodies to A?1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects.
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Academic Article
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The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.
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Academic Article
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Relationship between Alzheimer's disease clinical stage and Gq/11 in subcellular fractions of frontal cortex.
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Academic Article
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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
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Academic Article
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Plasma biomarkers of depressive symptoms in older adults.
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Academic Article
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FASTKD2 is associated with memory and hippocampal structure in older adults.
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Academic Article
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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
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Academic Article
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A novel Alzheimer disease locus located near the gene encoding tau protein.
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Academic Article
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miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
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Academic Article
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Novel genetic loci underlying human intracranial volume identified through genome-wide association.
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Academic Article
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Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
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Academic Article
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The complex genetics of gait speed: genome-wide meta-analysis approach.
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Academic Article
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Novel genetic loci associated with hippocampal volume.
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Academic Article
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TOMM40'523 variant and cognitive decline in older persons with APOE e3/3 genotype.
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Academic Article
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Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample.
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Academic Article
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Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies.
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Academic Article
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Selective lowering of synapsins induced by oligomeric a-synuclein exacerbates memory deficits.
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Academic Article
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
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Academic Article
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Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cells.
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Academic Article
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Soluble Conformers of A? and Tau Alter Selective Proteins Governing Axonal Transport.
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Academic Article
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Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.
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Academic Article
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APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.
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Academic Article
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Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
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Academic Article
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Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice Brains.
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Academic Article
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Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.
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Academic Article
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A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.
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Academic Article
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Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.
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Academic Article
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Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease.
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Academic Article
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High-resolution serum proteomic profiling of Alzheimer disease samples reveals disease-specific, carrier-protein-bound mass signatures.
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Academic Article
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Distinct subcellular patterns of neprilysin protein and activity in the brains of Alzheimer's disease patients, transgenic mice and cultured human neuronal cells.
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Academic Article
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Biomarker discovery and analysis platform: application to Alzheimer's disease.
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Academic Article
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Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
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Academic Article
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Functional links between A? toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
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Academic Article
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Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.
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Academic Article
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Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE e4 haplotype status: a community-based cohort study.
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Academic Article
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The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.
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Academic Article
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Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.
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Academic Article
|
Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons.
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Academic Article
|
Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.
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Academic Article
|
Association of Cortical ?-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.
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Academic Article
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Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.
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Academic Article
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Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.
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Academic Article
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Cognition may link cortical IGFBP5 levels with motor function in older adults.
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Academic Article
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Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.
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Academic Article
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Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes.
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Academic Article
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Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.
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Academic Article
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Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
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Academic Article
|
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.
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Academic Article
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A? (Amyloid Beta) and Tau Tangle Pathology Modifies the Association Between Small Vessel Disease and Cortical Microinfarcts.
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Academic Article
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TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks.
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Academic Article
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Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample.
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Academic Article
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Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.
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Academic Article
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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
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Academic Article
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Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.
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Academic Article
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A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease.
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Academic Article
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Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
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Academic Article
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Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
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Academic Article
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Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies.
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Academic Article
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Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
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Academic Article
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Inferring protein expression changes from mRNA in Alzheimer's dementia using deep neural networks.
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Academic Article
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Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease.
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Academic Article
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Identification of the A?37/42 peptide ratio in CSF as an improved A? biomarker for Alzheimer's disease.
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Academic Article
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Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults.
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Academic Article
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Mitochondrial respiratory chain protein co-regulation in the human brain.
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Academic Article
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FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease.
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Concept
|
Forkhead Box Protein O3
|
Concept
|
ORAI2 Protein
|
Concept
|
Valosin Containing Protein
|
Concept
|
Disks Large Homolog 4 Protein
|
Concept
|
Protein-Arginine Deiminases
|